During World War II, pre-filled syringes appeared for the first time in order to meet the needs of field hospitals for on-site aseptic medical treatment. Prefilled syringes were once again strongly introduced to the market in the early 1950s, when Becton Dickinson provided glass prefilled syringes for Dr. Jonas Salks' polio vaccine project. Since then, prefilled syringes have continued to be used, mostly in the field of insulin and human growth hormone administration. However, the pre-filled syringe has really become popular in the past 5 years, and it has almost become a product that injection suppliers must provide. Most innovative liquid medicines, if appropriate, will be put on the market in syringes.
The popularity of pre-filled syringes is mainly due to the advantages of the product itself.
The easy-to-use pharmaceutical market is changing, and the number of biotech therapies and drug candidates that can only be administered by injection is increasing. They involve a wide range of treatment fields, such as multiple sclerosis, infertility, osteoporosis, hepatitis, rheumatoid Arthritis, cancer, anemia and hemophilia, etc. Some biotech drugs require frequent injections and administration by the patients themselves. They benefit the most from the convenience of pre-filled syringes, because pre-filled syringes save some steps and make use faster and easier.
The needs of patients are the real power to promote the development of prefilled syringes. Measuring out the medicine from the vial into the syringe is a time-consuming task, and it is easy for people who lack adequate training to make mistakes. In addition, patients with certain diseases such as rheumatoid arthritis often have difficulty, or even can not hold the vial firmly and measure the accurate dose. Pharmaceutical manufacturers have changed some drugs from freeze-dried dosage forms to liquid dosage forms for easy loading into pre-filled syringes, such as Berlex’s multiple sclerosis drug Betaseron, Novo Nordisk’s human growth hormone Norditropin, and Genentech’s human growth Nutropin has been changed from a lyophilized dosage form to a liquid dosage form and sold in pre-filled syringes.